The blood clots, autoimmune damage, myocarditis, lipid nanoparticles, they new about all of it, all along.
This week saw Katalin Karikó and Drew Weissman awarded the 2023 Nobel Prize in Medicine for their role in developing the mRNA technology underlying the Pfizer-BioNTech and Moderna COVID-19 vaccines, which were rolled out in late 2020.
According to a press release for the award: the discoveries by the two Nobel Laureates were critical for developing effective mRNA vaccines against COVID-19 during the pandemic that began in early 2020. Through their groundbreaking findings, which have fundamentally changed our understanding of how mRNA interacts with our immune system, the laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times.
However, in a paper published in 2018 and which is extensively quoted in an article at MedPageToday, Drew Weissman warned that prior clinical trials of mRNA vaccines had produced results which were “more modest in humans than was expected based on animal models… and the side effects were not trivial”, including “moderate and in rare cases severe injection site or systemic reactions”. Further summarising the paper by Weissman and three colleagues in Nature Reviews Drug Discovery, MedPageToday notes:
"Their chief safety concerns, which they said should be closely watched in future trials, were about local and systemic inflammation, as well as keeping tabs on the “expressed immunogen” and on any auto-reactive antibodies."
“A possible concern could be that some mRNA-based vaccine platforms induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity,” they wrote. “Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken.”
The authors also noted that extracellular RNA could contribute to edema, and cited a study that showed it “promoted blood coagulation and pathological thrombus formation.”
The MedPageToday article is titled ‘Want to Know More About mRNA Before Your Covid Jab?
Pathologist Dr Claire Craig expertly summarised it